Tuesday, June 15, 2010

Estimulação Magnética com Bobina "H".


Equipe do IPAN participa de estudo para novo modelo de Estimulação Magnética.

Pesquisadores de Israel criam novo modelo de bobina para EMTr.

Um novo modelo de Estimulação Magnética Transcraniana repetitiva (EMTr) foi desenvolvido em Israel. A principal mudança é na bobina utilizada na técnica, denominada H. A novidade é muito importante no arsenal terapêutico da Estimulação Magnética Transcraniana de repetição (EMTr). Ela foi criada em Israel e será testada em um estudo multidisciplinar. A finalidade é emitir estímulos mais profundos e abrangentes, aumentando a eficácia do tratamento. A equipe de Israel apresentou bons resultados e quase nenhum efeito colateral foi relatado. A bobina H (HESED) vem do Hebraico que significa Compaixão, para os pesquisadores, a grande aposta é que a Compaixão trata depressão.

A equipe de Estimulação Magnética do IPAN recebeu a grande honra de poder participar deste estudo na Universidade de Columbia e contribuir para a Ciência e avanços do tratamento dos pacientes de depressão.

Abaixo o resumo do artigo com resultados preliminares:

A randomized controlled feasibility and safety study of deep transcranial magnetic stimulation.

OBJECTIVE: The H-coils are a new development in transcranial magnetic stimulation (TMS) research, allowing direct stimulation of deeper neuronal pathways than does standard TMS. This study assessed possible health risks, and some cognitive and emotional effects, of two H-coil versions designed to stimulate deep portions of the prefrontal cortex, using several stimulation frequencies.

METHODS: Healthy volunteers (n=32) were randomly assigned to one of four groups: each of two H-coil designs (H1/H2), standard figure-8 coil, and sham-coil control. Subjects were tested in a pre-post design, during three increasing (single pulses, 10 Hz, and 20 Hz) stimulation sessions, as well as 24-36 h after the last stimulation.

RESULTS: The major finding of the present study is that stimulation with the novel H-coils was well tolerated, with no adverse physical or neurological outcomes. Computerized cognitive tests found no deterioration in cognitive functions, except for a transient short-term effect of the H1-coil on spatial recognition memory on the first day of rTMS (but not in the following treatment days). On the other hand, spatial working memory was transiently improved by the H2-coil treatment. Finally, the questionnaires showed no significant emotional or mood alterations, except for reports on 'detachment' experienced by subjects treated with the H1-coil.

CONCLUSIONS: This study provides additional evidence for the feasibility and safety of the two H-coil designs (H1/H2).

SIGNIFICANCE: The H-coils offer a safe new tool with potential for both research and clinical applications for psychiatric and neurological disorders associated with dysfunctions of deep brain regions.

Levkovitz Y, Roth Y, Harel EV, Braw Y, Sheer A, Zangen A. Clin Neurophysiol. 2007 Dec;118(12):2730-44. Epub 2007 Oct 30.


IPAN - Instituto de Pesquisas Avançadas em Neuroestimulação
Rua Vergueiro, 1855 - Cj 42b - Vila Mariana - São Paulo - SP
Tel: (11) 5083-0342
Email: ipan@ipan.med.br
http://www.ipan.med.br

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