Tuesday, June 15, 2010

EMTr para Depressão e Pânico


A Estimulação magnética transcraniana repetição (EMTr) vem sendo pesquisada para Depressão e Transtorno do pânico.

O Dr. Mantovani e equipe (Universidade de Columbia-NY) estão desenvolvendo uma pesquisa de Estimulação magnética transcraniana repetição (EMTr) para Depressão e Transtorno do pânico. Oito pacientes já se beneficiaram deste método. Eu estou acompanhando esta pesquisa e ela tem sido feita da seguinte forma: EMTr com estímulo lento, localizada no lado direito, durante 30 minutos e por 4- 8 semanas de duração . Em resultados preliminares, o estudo apresentou resultados positivos e sem efeitos colaterais.

Abaixo segue a publicação dos dados preliminares desta pesquisa:

Repetitive Transcranial Magnetic Stimulation (rTMS) in the treatment of panic disorder (PD) with comorbid major depression.

BACKGROUND: Studies suggest that the dorsolateral prefrontal cortex (DLPFC) participates in neural circuitry that is dysregulated in Panic Disorder (PD) and Major Depressive Disorder (MDD). We tested whether low-frequency repetitive Transcranial Magnetic Stimulation (rTMS) could normalize the overactivity of right frontal regions and thereby improve symptoms.

METHODS: Six patients with PD and comorbid MDD were treated with daily active 1-Hz rTMS to the right DLPFC for 2 weeks in this open-label trial.

RESULTS: Clinical improvements were apparent as early as the first week of treatment. After the second week, 5/6 of patients showed improvements in panic and anxiety, and 4/6 showed a decrease in depression, with sustained improvement at 6 months of follow-up. Right hemisphere resting motor threshold increased significantly after rTMS.

LIMITATIONS: Limitations of this study are the open design and the small sample size.

CONCLUSIONS: Slow rTMS to the right DLPFC resulted in significant clinical improvement and reduction of ipsilateral motor cortex excitability. Replications in larger sample will help to clarify the relevance of this preliminary data and to define the potential role of right DLPFC rTMS in panic with major depression.

Mantovani A, Lisanby SH, Pieraccini F, Ulivelli M, Castrogiovanni P, Rossi S. J Affect Disord. 2007 Sep;102(1-3):277-80.


IPAN - Instituto de Pesquisas Avançadas em Neuroestimulação
Rua Vergueiro, 1855 - Cj 42b - Vila Mariana - São Paulo - SP
Tel: (11) 5083-0342
Email: ipan@ipan.med.br
http://www.ipan.med.br

No comments:

Post a Comment